Isopropylphenidate

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Isopropylphenidate (also known as IPH, IPPH, IPD and IPPD) is novel lesser-known stimulant of the phenidate chemical class. It is a structural analog of the widely-prescribed ADHD medication methylphenidate. It is a norepinephrine–dopamine reuptake inhibitor (NDRI).

Isopropylphenidate has been investigated for its potential use as a replacement for methylphenidate in the treatment of ADHD and related disorders. One study found that it displayed the same basic activity as a norepinephrine–dopamine reuptake inhibitor (NDRI), possessing, along with both methylphenidate and ethylphenidate, an appreciably high affinity for the dopamine transporter and effects on its cellular reuptake. It displayed comparably minor effects on norepinephrine, however, which was theorized to mean it may possess a more desirable safety and toxicity profile.

Subjective effects include stimulation, motivation enhancement, appetite suppression, and euphoria. Its cognitive and physical effects are reported to be similar to methylphenidate, albeit with less of a euphoric “rush” component and a drawn-out duration of action. These properties have led some to claim it may be preferable for use as a study-aid or productivity enhancer.

Isopropylphenidate has an extremely short history of recreational use in humans. It was initially released following the banning of ethylphenidate, which on April 2015 became illegal in the United Kingdom following a temporary-then-permanent blanket ban. Shortly after, it became made available for sale on the online gray market as a research chemical for global distribution. As of 2022, isopropylphenidate continues to remain available and ambiguously legal in many parts of the world, distributed almost exclusively by online research chemical vendors.Buy Isopropylphenidate online UK , Isopropylphenidate for sale England , Order Isopropylphenidate Wales, Where to buy Isopropylphenidate Scotland

Chemistry

Isopropylphenidate is a synthetic molecule of the substituted phenethylamine, substituted amphetamines and phenidate classes. It contains a phenethylamine core featuring a phenyl ring bound to an amino (NH₂) group via an ethyl chain. It is structurally similar to amphetamine, featuring a substitution at R_α which is then incorporated into a piperidine ring ending at the terminal amine of the phenethylamine chain. Additionally, it contains an isopropyl acetate bound to R_β of its molecular structure, a noticeable departure from methylphenidate, which contains a methyl group in this position.

Isopropylphenidate structurally diverges from ethylphenidate and methylphenidate by the length of the carbon chain on their acetate group. Iso- regards the side chain of one carbon atom branching into two bound methyl groups, phen- indicates the phenyl ring, id- is contracted from the piperidine ring, and -ate indicates the acetate group. Isopropylphenidate is a chiral compound, and has been documented as being produced as a racemic mixture and exclusively as either of its enantiomers.

Pharmacology

Formal in-vivo human studies using isopropylphenidate have not been conducted. However, in vivo rat studies have found stimulatory effects; in vitro studies have evaluated the monoamine transporter binding affinities and affinities for various hydrolytic enzymes respectively.The results of these studies suggest that isopropylphenidate has a very similar pharmacology to its parent compound methylphenidate, with the notable differences between the two substances being isopropylphenidate displaying significantly less activity as a norepinephrine reuptake inhibitor and the CES1 hydrolytic enzyme, which is exclusively responsible for hydrolysing both substances to ritalinic acid, having an 8 times lower affinity for isopropylphenidate compared to methylphenidate.

These differences result in the substance having more notable dopaminergic activity than adrenergic activity compared to methylphenidate at equivalent effective dosages, and in the substance having a longer duration than methylphenidate and a greater potency than methylphenidate at a given dosage. The greater potency of isopropylphenidate compared to methylphenidate is most significant with oral administration as the difference in potency is a result of the lower affinity of CES1 increasing the bioavailability of isopropylphenidate compared to methylphenidate, which is notably low for methylphenidate when administered orally due to first-pass metabolism in the liver by CES1.

Despite the notable differences between the two substances, isopropylphenidate is still thought to act primarily as both a dopamine reuptake inhibitor and a norepinephrine reuptake inhibitor, meaning that it effectively boosts the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the brain, resulting in stimulatory effects.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• 25x-NBOMe & 25x-NBOH – 25x compounds are highly stimulating and physically straining. Combinations with Isopropylphenidate should be strictly avoided due to the risk of excessive stimulation and heart strain. This can result in increased blood pressure, vasoconstriction, panic attacks, thought loops, seizures, and heart failure in extreme cases.
• Alcohol – Combining alcohol with stimulants can be dangerous due to the risk of accidental over-intoxication. Stimulants mask alcohol’s depressant effects, which is what most people use to assess their degree of intoxication. Once the stimulant wears off, the depressant effects will be left unopposed, which can result in blackouts and severe respiratory depression. If mixing, the user should strictly limit themselves to only drinking a certain amount of alcohol per hour.
• DXM – Combinations with DXM should be avoided due to its inhibiting effects on serotonin and norepinephrine reuptake. There is an increased risk of panic attacks and hypertensive crisis, or serotonin syndrome with serotonin releasers (MDMA, methylone, mephedrone, etc.). Monitor blood pressure carefully and avoid strenuous physical activity.
• MDMA – Any neurotoxic effects of MDMA are likely to be increased when other stimulants are present. There is also a risk of excessive blood pressure and heart strain (cardiotoxicity).
• MXE – Some reports suggest combinations with MXE may dangerously increase blood pressure and increase the risk of mania and psychosis.
• Dissociatives – Both classes carry a risk of delusions, mania and psychosis, and these risk may be multiplied when combined.
• Stimulants – Isopropylphenidate may be dangerous to combine with other stimulants like cocaine as they can increase one’s heart rate and blood pressure to dangerous levels.
• Tramadol – Tramadol is known to lower the seizure threshold^[8] and combinations with stimulants may further increase this risk.

• MAOIs – This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, and some antidepressants.
• MDMA – The neurotoxic effects of MDMA may be increased when combined with other stimulants.